Testolone RAD-140 Liquid

What is RAD 140 (Testolone)?

RAD 140, otherwise known as Testolone, is a type of Selective Androgen Receptor Modulator (SARMs). It was originally developed to be an alternative to testosterone replacement therapy. It should not be confused with its esterified form, RAD 150, otherwise known as TLB 150. Like other SARMs, RAD140 binds selectively to the androgen receptor (AR) and does not cause the full scope of androgenic effects as substances like testosterone, DHT, or anabolic steroids.
RAD 140 has a very high affinity for AR in comparison to DHT and most anabolic steroids (Ki=7 nM) [1]. For reference, this pre-clinical model showed the affinity for the AR for testosterone at 29 nM and 10 nM for DHT. Unlike testosterone and most other AR-mediated anabolic agents, Testolone is orally bioavailable, so it doesn’t require injections for proper absorption. This attribute makes it one of the most efficient SARMs for bulking up and gaining lean body mass.

When was Testolone Developed?

Testolone is a fairly recent addition to the list of SARMs for sale, having been developed in 2010. Initially created as a potential therapeutic option for osteoporosis and muscle increases, recent studies undertaken on rodents, primates, and humans have identified extra advantages in some form.

Muscle Growth and RAD140

Exploring the anabolic effects of RAD140 in a study on young male cynomolgus monkeys over 28 days, researchers looked at three doses to monitor its impact: 0.01mg/kg, 0.1mg/kg, and 1mg/kg per day. On average, a gain in weight of 10% was observed in both the 0.1mg/kg/day and the 1mg/kg/day groups heralding a dose-response curve that peaked without further advantage when higher dosages were introduced. Interestingly, there wasn’t any indication of changes in body fat mass for either group though increases in muscle mass occurred with 0.1 and 1 mg/kg/day groups, respectively. Likewise, no signs of increased liver enzymes or prostate weight existed, implying high selectivity towards androgen receptors around the muscle tissue [1].

What is the Role of Androgens in Alzheimer's Disease?

Androgens have demonstrated a significant clinical benefit in the prevention of neuronal apoptosis and enhancement of cognitive function in those with Alzheimer’s Disease (AD). This appears to primarily occur through a nongenomic mechanism involving the Androgen Receptor. Rapid phosphoinositide 3-kinase/Akt signaling activated by androgens can regulate the expression of proteins associated with apoptosis, such as Bax, Saladin 1, survivin, XIAP, and bcl-xl [8]. Moreover, androgen administration may help maintain the integrity of neurons, thereby improving cognitive performance [9].
Studies have revealed that Aβ impairs synaptic structure and function in hippocampal neurons, yet these impairments can be reversed by androgen treatment, resulting in increased cognitive abilities within AD animal models. While definitive mechanisms for this process remain unknown, it is believed that androgens play a role in inhibiting Aβ-induced apoptosis [9]

Can RAD140 Offer Neuroprotection?

A 2014 study assessed the potential of RAD140 for delivering neuroprotection, both in vitro and in vivo. In vitro experiments showed that RAD140 could protect cells from death and restore mitochondrial membrane potential, much like testosterone and other compounds investigated for this purpose. In vivo, male rats with kainate-induced seizures experienced a marked reduction in seizure activity after treatment with RAD140 compared to control subjects [2].

These results suggest that RAD140 may one day prove to be a viable therapeutic option for neurological disorders. Findings from the experiment opened up further research possibilities involving the use of RAD140 to treat a range of pathological processes associated with neurological disorders such as Parkinson's disease or Alzheimer's disease.

What was the extent of RAD140's Neuroprotective Benefits?

A study conducted on rats found that RAD140 had remarkable neuroprotective benefits that could potentially be used to prevent diseases such as Alzheimer's while being safer than traditional hormone therapy [3]. The group which received a dose of 3 milligrams per kilogram (mg/kg) of RAD140 could achieve a similar degree of muscular growth as those who took in 1 mg/kg of Testosterone, yet only bare half the androgenic activity in the prostate.. Evidently, RAD140 provided an advantageous alternative to traditional hormone treatments [3].

What potential does RAD140 have as a therapeutic option for treating AR/ER positive breast cancer?

A 2017 study investigated the potential of RAD140 in treating AR/ER positive breast cancer. The findings suggested that this compound had the capability to inhibit the growth and metastases of these cells without causing any disruption to the cell cycle, indicating it may be a promising therapy [4]. Additionally, its mode of action was distinct from other anti-estrogens and aromatase inhibitors, implying that it may provide an additional treatment approach for hormone-sensitive breast cancers.
Overall, results showed that RAD140 might be a viable therapeutic option for treating AR/ER positive breast cancer. However, further data is needed to assess its safety in comparison to current treatments.

What Is Known About the Potential Side Effects of RAD 140?

RAD 140 is a Selective Androgen Receptor Modulator (SARM) that has been found to be effective for bodybuilding, amongst other uses. While generally, it does not cause androgenic side effects as strongly as anabolic steroids such as testosterone, anecdotal reports have suggested nausea, aggression, or mild male pattern hair loss may arise from its usage.

A single case report indicated potential drug-induced liver injury after the subject had taken an anti-depressant over 11 months, along with intermittent use of RAD 140 and LGD-4033. This study's limitations are that only one person was tested; the quality and dosage of SARMs used by this individual were not monitored; extended antidepressant use; and underlying comorbidities were not investigated [7].

There are several case studies demonstrating a potential link between SARMs like RAD 140 and liver injury, but no significant sample size or control groups have yet been studied so far. Similar to other types of SARMs, RAD 140 may prompt a negative feedback loop resulting in reduced natural testosterone production and testicle size, though more research needs to be done to establish this proceeding's likelihood and intensity.

FAQ's For Rad 140

What does research indicate about the effect of RAD 140 on testosterone levels?

A study conducted in 2010 revealed that after a 28-day dosage of RAD140, the testosterone levels of each group were suppressed to around 200 to 300 ng/dL. All three groups exhibited the same level of suppression. However, the 0.01 mg/kg group had lower testosterone levels than the other two groups (p \u003c 0.05) [6]. The outcome indicates that Research And Development 140 appears to inhibit natural testosterone output.

What is the Safety Profile of RAD 140 for Women?

RAD 140 is not particularly known to be androgenic. However, there is limited data regarding its safety profile in women, making it necessary to exercise caution when considering participating in clinical research with RAD 140 until more information becomes available.
The long-term effects of RAD 140 on female bodies are not known since most studies have focused on male subjects. Thus far, no reports of adverse events specific to women have been documented in the studies that have already been completed. In addition, the impact of other hormones, such as estrogen and progesterone, on their interaction with RAD 140 has yet to be determined.
Therefore it is important for prospective women participants to discuss any potential risks and benefits with their doctors before taking part in any research involving RAD 140. It may also be beneficial for medical professionals who are monitoring participants during trials to keep a close eye on possible side effects or symptoms that could be unique to females. Furthermore, because this compound behaves differently in different genders due to differences in physiology, regular checkups become even more important than usual, especially when starting out a cycle.“

Can RAD 140 lead to hair loss?

While there has been no evidence suggesting that RAD 140 is a highly androgenic compound, it is possible that its administration could result in an increase of free testosterone in the male body. Free testosterone is usually bound to sex hormone-binding globulin (SHBG), and it can cause hair loss indirectly.
Studies conducted on mice demonstrate the use of RAD 140 has the potential for stimulating the body's natural production of male hormones such as testosterone, which in turn can influence hair growth. Suppose a person experiences an increase in testosterone levels due to this supplementation. In that case, they may also be more likely to develop pattern baldness or experience some level of hair thinning or shedding.
However, it ultimately depends on the individual's genetic predisposition since factors such as family history and existing health conditions related to hormone imbalance play a role in whether they're likely to experience any adverse effects from using RAD 140. There are also other therapeutic drugs that might reduce the risk of developing hair loss as well such as finasteride, although this should be discussed with a doctor about possible side effects before starting treatment.

What makes Sarm Labz the best place to purchase RAD140 and Is RAD 140 For Sale Online?

Sarm Labs is the best source for purchasing RAD140 online due to the consistent, verifiable high quality products, secure packaging and bottling, efficient shipping, and excellent customer service. Recent research on 44 different SARMs sold on the internet revealed that their quality varies from one company to another: only 52% of products tested contained relevant components; 59% contained amounts that deviated from what was indicated on labels; 39% contained unapproved drugs; 25% had a mixture of substances not listed in any way; 9% did not contain active components whatsoever. Therefore, it is vital to acquire just top-notch verified goods during research involving SARMs.
RAD140 has been deemed by numerous people as one of the best SARMs for build up and gaining muscle mass. While there are many websites where it can be found, only Sports Technology Labs ensures maximum safety with its goods. Our company provides 98%-pure compounds that have passed accreditation exams carried out by American third-party labs. To assure that contents remain undamaged, all our products come in glass containers along with stable glass tube droppers securing long shelf life with no external measuring instruments' contamination when used repeatedly. Moreover, we practice honest and open activities with zero unnecessary discreet payment methods or deceiving representations of our items; a 60-day revocable guarantee system further backs this up. By choosing us, you will be opting for a great deal and the most exceptional RAD140 concerning both powder or liquid form options! In addition, we always prioritize satisfactory client service without fail. You are welcome to contact us if any questions arise about our RAD140!

Abuse and Warnings

RAD140 is an investigational chemical substance that has yet to receive approval from the FDA and is not a dietary supplement. Sarm Labz, a company specializing in sourcing and quality control of chemicals, cautions against the utilization of SARMs products. It should only be used under the advice and guidance of a medical doctor or designated research authority.
Anecdotal reports have indicated its use at dosages of 10mg and 20mg per day by many individuals, while some forums list even 30mg per day doses being taken by several people. However, these dosages might not match those used in properly designed medical protocols, thus increasing the risk of potential adverse effects for the user. The replicating of these unverified protocols online is highly dangerous and must be avoided altogether.
Sarm Labz discourages the usage of SARMs for performance enhancement in sports or bodybuilding since results can never be guaranteed without proper medical examinations or adequate research protocols being followed first. Similarly, “bro science” or peer consensus should never be relied on when making decisions about human health.

References:

1. Miller, C. P., Shomali, M., Lyttle, C. R., O’Dea, L. S., Herendeen, H., Gallacher, K., Paquin, D., Compton, D. R., Sahoo, B., Kerrigan, S. A., Burge, M. S., Nickels, M., Green, J. L., Katzenellenbogen, J. A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective AR Modulator (SARM) RAD140. ACS medicinal chemistry letters, 2(2), 124–129. GW 501516 https://pubs.acs.org/doi/10.1021/ml1002508
2. Jayaraman, A., Christensen, A., Moser, V. A., Vest, R. S., Miller, C. P., Hattersley, G., & Pike, C. J. (2014). Selective AR modulator RAD140 is neuroprotective in cultured neurons and kinate-lesioned male rats. Endocrinology, 155(4), 1398–1406. https://doi.org/10.1210/en.2013-1725
3. D. K. Hamson, S. R. Wainwright, J. R. Taylor, B. A. Jones, N. V. Watson, L. A. M. Galea, Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats, Endocrinology, Volume 154, Issue 9, 1 September 2013, Pages 3294–3304, https://doi.org/10.1210/en.2013-1129
4. Yu, Ziyang et al. “Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive BC Models with a Distinct Mechanism of Action.” MK 677 Clinical Cancer Research 23 (2017): 7608 – 7620.
5. LoRusso P, Hamilton E, Ma C, Vidula N, Bagley RG, Troy S, Annett M, Yu Z, Conlan MG, Weise A. A First-in-Human Phase 1 Study of a Novel Selective AR Modulator (SARM), RAD140, in ER+/HER2- Metastatic BC. Clin Br Cancer. 2022 Jan;22(1):67-77. doi: 10.1016/j.clbc.2021.08.003. Epub 2021 Aug 20. PMID: 34565686.
6. Miller, C. P., Shomali, M., Lyttle, C. R., O’Dea, L. S., Herendeen, H., Gallacher, K., Paquin, D., Compton, D. R., Sahoo, B., Kerrigan, S. A., Burge, M. S., Nickels, M., Green, J. L., Katzenellenbogen, J. A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective AR Modulator (SARM) RAD140. ACS medicinal chemistry letters, 2(2), 124–129 https://doi.org/10.1021/ml1002508
7. Flores JE, Chitturi S, Walker S. Drug-Induced Liver Injury by Selective Androgenic Receptor Modulators. Hepatol Commun. 2020 Jan 3;4(3):450-452. doi: 10.1002/hep4.1456. PMID: 32140660; PMCID: PMC7049679.
8. Bing L, Wu J, Zhang J, Chen Y, Hong Z, Zu H. DHT inhibits the Aβ25-35-induced apoptosis by regulation of seladin-1, survivin, XIAP, bax, and bcl-xl expression through a rapid PI3-K/Akt signaling in C6 glial cell lines. Neurochem Res. 2014;40(1):41–48.
9. Huo DS, Sun JF, Zhang B, Yan XS, Wang H, Jia JX, Yang ZJ. Protective effects of testosterone on cognitive dysfunction in Alzheimer’s disease model rats induced by oligomeric beta amyloid peptide 1–42. J Toxicol Environ Health A. 2016;79(19):856–863.
10. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010. doi: 10.1001/jama.2017.17069. Erratum in: JAMA. 2018 Feb 20;319(7):724. PMID: 29183075; PMCID: PMC5820696.

Related Products