Cardarine GW-501516 Capsules

What is Cardarine?

Cardarine, also known as GW501516 or Endurobol, is a PPAR (peroxisome proliferator-activated receptor) agonist and ligand-activated transcription factor. It binds to receptors in skeletal muscle tissue and body fat, pushing cells towards preferential lipid utilization and encouraging fat burning. As well as being involved in inflammation, glucose homeostasis, cell proliferation, differentiation, and apoptosis - it can potentially even have anti-aging effects.
PPARs are most prevalent in tissues with higher metabolic rates, such as skeletal muscle, intestine, liver, heart, and kidney. GW-501516 is often mistaken for a selective androgen receptor modulator or SARM. While maintaining certain resemblances to this category of compounds - it differs from them in several ways. Unlike SARMs GW 501516 does not affect testosterone levels, nor does it have any impact on the androgen receptors. Despite this, however, it still has key involvement within energy metabolism processes.

What is Cardarine and Its Mechanism of Action?

Cardarine, or GW1516 or GSK-516, was invented in the early 1990s. It has a high affinity (Ki = 1 nM) and potency for PPARδ and displays over 1,000-fold selectivity toward PPARα and PPARγ [5]. When GW501516 binds to the PPARδ receptor, it recruits the coactivator PGC-1α, which then stimulates the expression of proteins involved in energy expenditure [6].
By activating AMP-activated protein kinase, Cardarine has become widely known for its many experimental effects. These include fat loss or fatty acid oxidation and even lower LDL cholesterol (“bad cholesterol”). It can lead to higher HDL cholesterol (“good cholesterol”), increased endurance, and reduced inflammation while decreasing insulin resistance and improving glucose tolerance.

What are the Benefits and Side Effects of PPAR?

PPAR, or Peroxisome proliferator-activated receptor, is a nuclear receptor that plays an important role in metabolism and physiological processes. It preserves glucose in tissues such as the brain while mobilizing fatty acids for muscular endurance [10]. Moreover, it has also been shown to be involved in temperature regulation, inflammation mediation, mitochondrial respiration, keratinocyte differentiation, and skin and muscle repair. Through molecular studies, these effects were seen to be regulated by the expression of certain genes associated with contractile proteins, lipid oxidation, and mitochondrial biogenesis [10].

Interestingly enough, the impacts of PPAR are evident during fasting when free fatty acids enter the bloodstream. Evidence from PPAR-null mice demonstrated that without PPAR in place, there's an elevated level of free fatty acids during fasting, which can result in lipid accumulation in the liver and heart, low blood sugar levels, low body temperatures, and ketones detected in urine eventually leading to premature death [14]. The adaptive nature of mice allows them to respond to high fatty acid levels through the induction of cardiac and hepatic PPARs, which increase fatty acid uptake and oxidation [15].

The effects of GW501516, however, remain uncertain as they have not been confirmed by any relevant authorities, such as FDA. This SARM, like all other SARMS for sale, should only be used for research purposes under no circumstances. Due to its associated potential benefits WADA (World Anti Doping Agency) has classified Cardarine as a banned substance among professional athletes; several individuals have allegedly tested positive for this drug with ensuing consequences.

What Do Studies Say About the Benefits of Cardarine?

A variety of research studies, both involving humans and animals, have pointed to the potential benefits offered by Cardarine. These include improved energy metabolism and enhanced blood lipids. For example, one study on mice found that GW501516 could promote fatty acid oxidation and fat burning in skeletal muscle tissue as well as helping to alleviate metabolic syndrome [1]. Another study looking at peroxisome proliferator-activated receptors (PPARs) showed an increased running endurance in Kunming mice [2].
Moreover, the results of a study involving obese rhesus monkeys provided evidence that Cardarine had an impact on increasing HDL levels while decreasing VLDL levels which could give rise to a potential cardio-protective effect [6]. This notion was also bolstered by two separate human trials, which showed positive effects when subjects were given Cardarine regarding obesity, diabetes, dyslipidemia, and cardiovascular disease while simultaneously showing suppression of macrophage-derived inflammation [7, 8].
Finally, in a study involving rats fed with a high fructose diet saw decreased inflammatory markers when taking GW 501516, along with an increase in gene expression for beta-oxidation processes [11].
These studies ultimately show how taking Cardarine can benefit various aspects of health and energy metabolism.

What are the Potential Side Effects of Cardarine?

Despite Cardarine not being commonly associated with androgenic side effects such as those caused by anabolic androgenic steroids, research on rats indicates that doses of 3 mg/kg/day (180-240 mg per day in humans weighing between 60-80 kg) could potentially lead to rapid cancerous growth in different organs [9]. While anecdotal reports online note little in terms of noticeable adverse reactions, more studies need to be done in order to better understand the overall safety of using GW501516 prior to any authorization for human usage.

FAQ's Fror Cardarine GW501516

Does GW 501516 Suppress Natural Testosterone?

GW 501516, or Cardarine, is a popular compound that promotes health benefits such as enhanced athletic performance. Though it has been used by bodybuilders and athletes alike, one of the primary uses of Cardarine is to help with weight loss. But does this compound suppress natural testosterone?
The answer to this question is no. GW 501516 does not interact with the body's androgen receptor, meaning that it won't cause suppression of natural testosterone levels at all. Instead, Cardarine stimulates fat metabolism while preserving muscle structures; additionally, this compound increases energy levels due to its mitochondrial stimulating property.
This means the only possible effects one might experience when taking Cardarine are an improved metabolic rate and increased energy levels—no side effects associated with hormone suppression. Furthermore, once you stop taking Cardarine, your hormones will return to normal quickly within days or weeks, depending on your dosage regimen.
In conclusion, GW 501516 does not affect a person's natural testosterone production and will not hamper any existing hormonal balance in the body; rather, it may improve performance without causing any adverse outcomes related to hormone suppression.

Can Women Participate in Cardarine Research?

Yes, research with Cardarine is accessible to women. Cardarine is a non-hormonal drug, and there have been no recorded instances of it causing virilization or interrupting menstrual cycles. Several clinical trials involving female test subjects were conducted with maximum dosages of up to 18mg per day. Pregnant women or women intending to become pregnant should avoid taking part in any such research concerning Cardarine, however.

What are the Benefits of Cardarine on Cholesterol?

Cardarine, or GW501516, is a PPAR-delta agonist that has demonstrated an ability to improve cholesterol levels. Specifically, it has been observed to increase levels of high-density lipoprotein (HDL) cholesterol while decreasing levels of low-density lipoprotein (LDL) cholesterol in clinical trials using rhesus monkeys. This action helps protect against cardiovascular health risks associated with high LDL and low HDL values.
The improved HDL and LDL balance may also be accompanied by numerous other metabolic benefits due to Cardarine's positive effect on fat Storing enzyme regulation. It has been presented as a potential treatment for obesity, diabetes, and dyslipidemia due to its ability to help induce better glycemic control and efficient energy storage pathways.
In terms of safety, research indicates relative safety with no apparent major side effects after 12 weeks of cardarine usage in human studies. With this said, however, there are still many unknowns about the long-term use of cardarine, so further research is needed before any definitive statements can be made about its exact effects on humans. In addition, pregnant and nursing women should avoid using cardarine as its effects in these cases remain unclear.
In conclusion, Cardarine appears to offer valuable potential when it comes to improving cardiovascular health by helping improve lipid profiles; however, further testing is necessary to define possible side effects and ensure safety standards down the road if one plans on taking it for extended periods of time.

Is Cardarine a SARM?

Cardarine is often labeled as a SARM (Selective Androgen Receptor Modulator) due to it being sold alongside other SARMs. However, in reality, it's a PPAR agonist and interacts with the body's PPAR receptors. These receptor sites are not primarily linked with anabolism, instead, they have roles in decreasing inflammation and boosting energy levels.
By activating PPAR receptors, Cardarine does influence human cells; but its involvement is limited when compared to full-blown steroids or SARMs. Its primary target of action lies within the metabolic system rather than the muscular-skeletal one commonly associated with anabolic compounds.
Unlike other SARMs, which mainly affect testosterone manufacture, Cardarine works differently and has added benefits like cholesterol control. This makes it safer than some other types of nutrition supplements that raise levels of certain hormones affecting muscle growth.
Because of this unique action on PPAR sites, it may have some advantages over traditional performance-enhancing supplements like creatine, giving strength and endurance gains as well as all-around better health from improved metabolic efficiency. This can mean quicker recovery times for athletes who take it during workouts for better results.
Overall, Cardarine serves as an alternative to traditional anabolic substances such as steroids or prohormones – but its effects within the body are fairly different though still beneficial to those looking for better physical performance and healthier muscles in general.

What Benefits Does Sarms Labz Offer When Buying Cardarine?

Sarm Labz is the optimal choice for purchasing Cardarine because of its consistent, reliable, high-grade products, secure shipping and packaging methods, fast carriers, and strong customer satisfaction. The organization also offers pure Cardarine powder.
When you buy SARMs from Sarm Labz, you can trust that their ingredients are 98% pure compounds that have been tested and certified by accredited American third-party labs, suspended in USP grade PEG 400, and enclosed in glass bottles with fixed glass droppers to avoid leakage of unwanted plasticizers like BPA. Their policies involve transparency, no hidden payments necessary, and accurate product descriptions - all backed up by their 60-day money-back guarantee policy.
At Sarm Labz one can receive SARMs for sale at great prices - including high-quality Cardarine for sale online more than any other vendor. This assurance makes it possible for customers to obtain the most potent GW 501516 form on today's market. Plus if you have any questions about liquid GW501516 products, you could get a speedy reply from service representatives.

Warnings and Abuse

Cardarine is an investigational compound that has not yet been approved by the US Food and Drug Administration (FDA). Sarm Labz is solely a supplier of chemicals for research purposes and does not provide medical advice. There are anecdotal reports online across various forums of individuals using 10mg and 20mg per day dosages of Cardarine, with some reporting daily use of up to 30mg. While these dosages may be outside the scope of carefully designed medical research protocols, they could present a risk of experiencing adverse side effects if used. We at Sarm Labz strongly advocate against the duplication of experimental protocols used on the consumer level as it can be hazardous to health. Moreover, we actively discourage consumers from using SARMs for performance enhancements in sports or bodybuilding activities and advise against following unprofessional “Bro Science” or peer consensus when making decisions regarding human health and wellbeing.

References:

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2. Chen, W. et al. A metabolomic study of the PPARd agonist GW501516 for enhancing running endurance in Kunming mice. Sci. Rep. 5, 09884; doi: 10.1038/srep09884 (2015) https://www.nature.com/articles/srep09884
3. Fan W., Waizenegger W., Lin C.S., Sorrentino V., He M.-X., Wall C.E., Li H., Liddle C., Yu R.T., Atkins A.R., et al. PPARδ Promotes Running Endurance by Preserving Glucose. Cell Metab. 2017;25:1186–1193.e1184. doi: 10.1016/j.cmet.2017.04.006 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492977/
4. https://sportstechnologylabs.com/gw501516/
5. Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5306-11. doi: 10.1073/pnas.091021198. Epub 2001 Apr 17. PMID: 11309497; PMCID: PMC33205.
6. Sprecher DL. Lipids, lipoproteins, and peroxisome proliferator activated receptor-delta. Am J Cardiol. 2007 Dec 3;100(11 A):n20-4. doi: 10.1016/j.amjcard.2007.08.009. PMID: 18047848.
7. Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006 Mar;116(3):590-7. doi: 10.1172/JCI27955. PMID: 16511591; PMCID: PMC1386117.
8. Dressel U, Allen TL, Pippal JB, Rohde PR, Lau P, Muscat GE. The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol. 2003 Dec;17(12):2477-93. doi: 10.1210/me.2003-0151. Epub 2003 Oct 2. PMID: 14525954.
9. Sahebkar A, Chew GT, Watts GF. New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. Expert Opin Pharmacother. 2014 Mar;15(4):493-503. doi: 10.1517/14656566.2014.876992. Epub 2014 Jan 16. PMID: 24428677.
10. Teresa Coll, David Álvarez-Guardia, Emma Barroso, Anna Maria Gómez-Foix, Xavier Palomer, Juan C. Laguna, Manuel Vázquez-Carrera, Activation of Peroxisome Proliferator-Activated Receptor-δ by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-κB Activation and Insulin Resistance in Skeletal Muscle Cells, Endocrinology, Volume 151, Issue 4, 1 April 2010, Pages 1560–1569, https://doi.org/10.1210/en.2009-1211
11. Magliano, D.C., Penna-de-Carvalho, A., Vazquez-Carrera, M. et al. Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine 50, 355–367 (2015). https://doi.org/10.1007/s12020-015-0590-1
12. Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010. doi: 10.1001/jama.2017.17069. Erratum in: JAMA. 2018 Feb 20;319(7):724. PMID: 29183075; PMCID: PMC5820696.
13. Burri L, Thoresen GH, Berge RK. The Role of PPARα Activation in Liver and Muscle. PPAR Res. 2010;2010:542359. doi: 10.1155/2010/542359. Epub 2010 Aug 18. PMID: 20847941; PMCID: PMC2933910.
14. Leone TC, Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7473-8. doi: 10.1073/pnas.96.13.7473. PMID: 10377439; PMCID: PMC22110.
15. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999 Jun;103(11):1489-98. doi: 10.1172/JCI6223. PMID: 10359558; PMCID: PMC408372.